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. 1997 Feb 4;94(3):967–972. doi: 10.1073/pnas.94.3.967

Figure 1.

Figure 1

In situ hybridization analysis of MUC 2 mRNA expression in non-CF and CF human bronchial explants. In situ hybridization was performed with the human airway mucin 1 anti-sense probe recognizing human MUC 2 mRNA as described (7). MUC 2 mRNA expression is shown in vehicle control-treated and P. aeruginosa-treated bronchial explant surface epithelia from non-CF (A and B) and CF (C and D) individuals and in vehicle control-treated and P. aeruginosa-treated bronchial explant submucosal glands from non-CF (E and F) and CF (G and H) individuals. Arrowheads in A–D indicate the position of the epithelial basement membrane. In these experiments, both non-CF and CF bronchial explants were exposed for 6 h to P. aeruginosa culture supernatants. Similar results were observed in bronchial explants from four CF and four non-CF individuals treated with P. aeruginosa strain PAO1 or PA103. L, airway lumen; SG, submucosal glands.