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Schematic representation of posttranslational events induced by CLOCK/BMAL1 interaction. There are three possible scenarios: CLOCK/BMAL1 phosphorylation occurs in the cytoplasm and is required for BMAL1-dependent nuclear translocation of the complex (A); unphosphorylated CLOCK/BMAL1 are translocated to the nucleus (B,C), where they get phosphorylated either before (B) or after (C) initiation of transcription (see text for details).
