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Accumulation of Stat1 in the nucleus is not sufficient to induce transcription. Wild-type Stat1 or the indicated DNA-binding mutants were coexpressed with an IFNγ-inducible luciferase reporter plasmid in U3A cells. Luciferase activity was determined 36 h posttransfection in unstimulated cells (gray bars) or after stimulation with IFNγ for 6 h (black bars). Error bars represent standard deviations for six independent experiments.
