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. 2003 Aug 15;17(16):2006–2020. doi: 10.1101/gad.1098703

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Figure 6. — dFOXO controls growth by affecting cell number. (A,B) Expression of dFOXO in fly eyes reduces eye size without affecting ommatidia size. (A) ey-Gal4/+. (B) ey-Gal4/UAS-dFOXO. (C) Overexpression of dFOXO in eye discs before the morphogenetic furrow (GMR-Gal4/UAS-dFOXO) causes a striking reduction of the eye size with severe ommatidia loss. (D–G) Overexpression of dFOXO in fly wings causes reduction in wing size by only affecting cell number. Values are the total average area in percent. (D) dpp-Gal4/+ (100% ± 7.8%). Arrows indicate the area affected by the driver. (E) dpp-Gal4/UAS-dFOXO (79.1% ± 5.2%). (F) MS1096-Gal4/+ (100% ± 2.9%). (G) MS1096-Gal4/UAS-dFOXO (60.4% ± 9.8%). (H–K) dAkt partially rescues the phenotype produced by dFOXO expression. (H) GMR-Gal4/+ +/+. (I) GMR-Gal4/+ UAS-dAkt/+. (J) GMR-Gal4/UAS-dFOXO +/+. (K) GMR-Gal4/UAS-dFOXO UAS-dAkt/+.

Figure 6. — dFOXO controls growth by affecting cell number. (A,B) Expression of dFOXO in fly eyes reduces eye size without affecting ommatidia size. (A) ey-Gal4/+. (B) ey-Gal4/UAS-dFOXO. (C) Overexpression of dFOXO in eye discs before the morphogenetic furrow (GMR-Gal4/UAS-dFOXO) causes a striking reduction of the eye size with severe ommatidia loss. (D–G) Overexpression of dFOXO in fly wings causes reduction in wing size by only affecting cell number. Values are the total average area in percent. (D) dpp-Gal4/+ (100% ± 7.8%). Arrows indicate the area affected by the driver. (E) dpp-Gal4/UAS-dFOXO (79.1% ± 5.2%). (F) MS1096-Gal4/+ (100% ± 2.9%). (G) MS1096-Gal4/UAS-dFOXO (60.4% ± 9.8%). (H–K) dAkt partially rescues the phenotype produced by dFOXO expression. (H) GMR-Gal4/+ +/+. (I) GMR-Gal4/+ UAS-dAkt/+. (J) GMR-Gal4/UAS-dFOXO +/+. (K) GMR-Gal4/UAS-dFOXO UAS-dAkt/+.