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(A) dFOXO is a key element of insulin signaling in Drosophila. The insulin receptor inactivates dFOXO through dPI3K/dAkt. Activation of d4EBP may explain growth inhibition by dFOXO, whereas activation of dInR may provide a novel transcriptionally induced feedback control mechanism for the pathway. (B) Model to explain regulation of growth by a feedback mechanism involving dInR and dFOXO.
