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Fancd2 mutants are predisposed to microphthalmia. (A) Fancd2 mutants are smaller than wild-type controls at postnatal day 1. Microphthalmia is visible in Fancd2 mutants. (B) Histology of eye from a wild-type control pup (postnatal day 1). Magnification, 50×. (C) Representative histology of eye from a Fancd2–/– pup (postnatal day 1) shows a disorganized retina with lack of a distinct chamber or lens development. Magnification, 100×.
