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Hypothetical mechanism of action of leptin to cause stimulation of LHRH release. For explanation, please see text. NPYn, NPY neuron; Leptin r, leptin receptor; NPYr, NPY receptor; NEn, noradrenergic neuron terminal; NOn, nitricoxidergic neuron; ARG, arginine; NOS, NO synthase; Cit, citrulline; α1r, α1 adrenergic receptor; gc, guanylate cyclase; cyclo, cyclooxygenase; PV, portal vessel; +, stimulation; −, inhibition.
