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. Author manuscript; available in PMC: 2008 May 25.
Published in final edited form as: Biochem Biophys Res Commun. 2007 Mar 30;357(1):139–143. doi: 10.1016/j.bbrc.2007.03.130

Figure 2. Hearts from αo-null mice show decreased sensitivity to muscarinic agonist.

Figure 2

A. Negative chronotropic responses to carbachol in isolated hearts from αo-null and littermate control (WT) mice. Hearts were perfused ex vivo in working or ejecting mode as described in methods. Carbachol dose response curves in the absence and presence of isoproterenol (1 μM, squares) were determined by increasing addition of carbachol. n = 5 for each group. By Two-Way ANOVA, P = 0.0071 WT vs. null; P < 0.0001 WT+ISO vs. null+ISO. Bonferroni post-tests, * P < 0.05 vs. WT; ** P < 0.01 vs. WT+ISO; *** P < 0.001 vs. WT+ISO. B, C. Negative chronotropic responses to carbachol in isolated hearts from αi2-null and αi3-null mice respectively. No statistical significance was detected.