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. Author manuscript; available in PMC: 2007 Sep 3.
Published in final edited form as: Bioorg Med Chem. 2006 Nov 1;15(2):663–677. doi: 10.1016/j.bmc.2006.10.060

Figure 2.

Figure 2

The lymphopenia evoked by the S1P agonist, 12b (VPC44152) is blocked by co-administration of the S1P receptor antagonist 12d (VPC44116). Groups of 3 C57BL/6 x sv129/J mice injected with vehicle (2% hydroxypropyl β-cyclodextrin), VPC44116 (22 mg/kg) and/or VPC44152 (18 mg/kg). After 16 hours, blood was drawn from the orbital sinuses and lymphocytes were measure with a Hemavet blood analyzer. Data are presented as mean ± S.E.