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. 2007 Aug 31;3(8):e170. doi: 10.1371/journal.pcbi.0030170

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© 2007 Bergman et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Longevity genes are expected to exhibit monotonic increase in their favorable genotype when sampled in progressively older age groups. The graph shows a highly significant (p < 0.0006) monotonic increased frequency across ages for favorable genotypes in APOC-3 CC, and a significant (p < 0.047) for CETP-VV, fulfilling our definition for candidate longevity genes.