Table 1.

General characteristics of subjects

Variable	n	Mean ± SD
Age, years	2776*	47.4±12.5
Postmenopausal, %	2453	47.7
Obesity-related variables:
Leptin, ng/ml	2776	16.5±12.0
BMI, kg/m2	2759	24.7±4.4
Weight, kg	2760	65.3±11.8
Waist, cm	2708	78.3±10.2
Total fat, kg	2719	23.4±8.8
Total fat, %	2678	35.6±8.0
Central fat, kg	2696	1.33±0.73
Central fat, %	2696	31.2±11.5
Insulin sensitivity:†
Fasting glucose, mmol/L	2317	4.49±0.55
Fasting insulin, μU/mL	1984	6.96±5.96
HOMA	1791	1.37±1.31
2h-glucose, mmol/L	738	5.18±1.10
2h-insulin, μU/mL	738	34.2±25.4
SiM	738	88.5±68.8

^*Number of subjects (846 MZ, 1930 DZ) with leptin data and genotype data on at least 1 SNP

^†Non-fasting subjects, patients with either type 1 or type 2 diabetes and patients on any anti-diabetic drugs were all excluded.

Type 2 diabetes: Diagnosed patients or subjects with fasting glucose>7.8mmol/L or 2h-glucose>11.1mmol/L.