Table 2.
Randomised studies of the renoprotective effect of lactulose and bile salts in jaundiced patients
| Authors | Year | Patient groups | n | Renal failure | Other end-points | Conclusion |
|---|---|---|---|---|---|---|
| Dawson24 | 1965 | Non jaundiced – biliary surgery | 12 | 0 | Fall in Cr clearance | |
| Jaundiced – surgery | 15 | 0 | Fall in Cr clearance | |||
| Jaundiced – surgery + mannitol | 7 | 0 | Attenuated fall in Cr clearance | Mannitol should be given | ||
| Gubern et al.25 | 1988 | VL | 14 | 1 | ||
| VL + mannitol | 17 | 2 | Cr clearance worse | Mannitol may be harmful | ||
| Parks et al.26 | 1994 | VL + frusemide | 10 | 0 | 2 (postoperative oliguria) | |
| VL + frusemide + LDD | 13 | 0 | 3 (postoperative oliguria) | No benefit | ||
| Wahbah et al.27 | 2000 | VL | 10 | 0 | No difference | |
| VL + LDD before surgery | 10 | 0 | No difference | No benefit | ||
| VL + LDD + mannitol | 10 | 0 | No difference | No benefit | ||
| VL + LDD + frusemide | 10 | 0 | Fall in Cr clearance | May be harmful |
VL, Volume loading; LDD, low dose dopamine.