Table 3.
Studies on the renoprotective effects of diuretic strategies in jaundiced patients
| Authors | Year | Patient groups | n | Renal failure | Other end-points | Authors' conclusion |
|---|---|---|---|---|---|---|
| Evans et al.22 | 1982 | No bile salts + VL | 9 | 2 | ||
| DCA + VL | 9 | 0 | Benefit to DCA | |||
| Pain et al.23 | 1985 | Lactulose + VL | 35 | 0 | Diarrhoea 34% | |
| DCA + VL | 32 | 0 | Benefit to DCA | |||
| VL | 35 | 1 | ||||
| Cahill et al.21 | 1987 | No bile salts + mannitol | 22 | 1 | Fall Cr clearance | |
| DCA + mannitol | 12 | 0 | Reduction in endotoxaemia | Benefit to DCA | ||
| Cr clearance maintained | ||||||
| CDCA + mannitol | 12 | 1 | Vomiting 10% | |||
| Fall Cr clearance |
DCA, Deoxycholic acid; CDCA, chenodeoxycholic acid; VL, volume loading.