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. Author manuscript; available in PMC: 2007 Sep 4.
Published in final edited form as: Anal Biochem. 2006 May 11;355(1):71–80. doi: 10.1016/j.ab.2006.04.045

Table 3.

IC50 values of sEH inhibitors determined with various test systems employing HsEH

Substrate Mode of measurement graphic file with name nihms21263t9.jpg graphic file with name nihms21263t10.jpg graphic file with name nihms21263t11.jpg graphic file with name nihms21263t12.jpg graphic file with name nihms21263t13.jpg
PHOME Continuous 9800 ± 2700 29 ± 13 33 ± 7 19 ± 2 4.6 ± 0.6
Endpoint 39,600 ± 4300 33 ± 3 35 ± 4 8.1 ± 0.5 5.5 ± 0.5
7a Continuous 7500 ± 130 25 ± 0.1 52 ± 1 7.0 ± 0.2 3.2 ± 0.1
NEPCa Continuous 42,000 ±2000 70 ± 20 160 ± 10 100 ± 10 100 ± 10
[3H]tDPPOa Endpoint ND 221 ± 2 63 ± 0.3 85.2 ± 0.5 69 ± 2

Note. Values (in nM) are given as means ± standard deviations (n ≥3). ND, not determined.

a

IC50 values are as reported previously (see Ref. [24] and references therein).