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. 2007 Sep 4;104(37):14801–14806. doi: 10.1073/pnas.0706919104

Fig. 1.

Fig. 1.

Selective distribution of netrin-G1 and -G2 proteins in distinct pathways. Coronal sections of adult mouse brain were stained with anti-netrin-G1 (A–C) and anti-netrin-G2 antibodies (D–F). Netrin-G1 and -G2 had a nonoverlapping and layer-specific distribution in the neocortex, piriform cortex, and hippocampus. Laminar organization (G), and distribution of netrin-G1 (H) and netrin-G2 (I) in the hippocampus. Netrin-G1 immunoreactivity was restricted to the terminal layers of the lateral perforant paths (LPP) in the DG and TA in CA1, whereas netrin-G2 was restricted to the terminal layers of the medial perforant paths (MPP) and SC. En, endopiriform nucleus; MML, middle molecular layer; OML, outer molecular layer; SLM, stratum lacunosum moleculare; SO, stratum oriens; SR, stratum radiatum. (J and K) Serial horizontal sections were hybridized with digoxigenin-labeled RNA probes. Note the complementary expression of Ntng1 and Ntng2 mRNAs in the LEC and MEC. [Scale bar: 200 μm (A and D); 250 μm (B, C, E, and F); 140 μm (G–I); 500 μm (J and K).]