Table 2.
Residue in human profilin 1 | Equivalent residue in human profilin 3 | Equivalent residue in ECTV-PH | Function in human profilin 1 |
W3 | W4 | W5 | Poly(L-proline) binding* |
Y6 | Y7 | I8 | Poly(L-proline) binding |
W31 | W32 | L33 | Poly(L-proline) binding |
Y59 | L60 | - | Actin binding |
V60 | Q61 | - | Actin binding |
N61 | A62 | - | Actin binding |
K69 | R70 | F67 | Actin and PIP2 binding |
S71 | C72 | I69 | Actin binding |
V72 | V73 | V70 | Actin binding* |
I73 | I74 | Y71 | Actin binding |
R74 | R75 | T72 | Actin binding |
E82 | D83 | T80 | Actin binding |
R88 | R89 | L86 | Actin and PIP2 binding |
K90 | K91 | G88 | Actin and PIP2 binding |
T97 | A95 | V92 | Actin binding |
N99 | A97 | P94 | Actin binding |
V118 | V116 | T113 | Actin binding |
H119 | H117 | S114 | Actin binding |
G121 | G119 | R116 | Actin binding |
L122 | I120 | E117 | Actin binding |
N124 | N122 | Y119 | Actin binding |
K125 | K123 | R120 | Actin and PIP2 binding* |
Y128 | H126 | R123 | Actin binding |
E129 | E127 | D124 | Actin binding* |
H133 | G131 | N128 | Poly(L-proline) binding |
L134 | L132 | V129 | Poly(L-proline) binding* |
R135 | R133 | R130 | PIP2 binding* |
R136 | M134 | A131 | PIP2 binding |
Y139 | A137 | N134 | Poly(L-proline) binding |