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. 2007 Aug 27;104(36):14519–14524. doi: 10.1073/pnas.0705740104

Fig. 2.

Fig. 2.

Analgesia evoked by KOR or DOR agonists in Lmx1bf/f/p and wild-type mice. (A) Saline and escalating doses of the KOR agonist U50,488H (1, 3, 6, 10, and 30 mg/kg s.c.) were administered to wild-type and Lmx1bf/f/p mice, and the analgesic effect was measured with the tail-flick assay. (B and C) The analgesic effect of the i.t. injection of U50,488H (60 μg) in Lmx1bf/f/p mice was comparable to wild-type mice (B), whereas effect of the i.c.v. injection of U50,488H (60 μg) was almost absent in Lmx1bf/f/p mice compared with that in wild type (C). (D and E) The analgesic effect of i.t. (D) and i.c.v. (E) injections of the DOR agonist [D-Pen2, D-Pen5]enkephalin (5 μg) in wild-type and Lmx1bf/f/p mice. All data are mean ± SEM. *, P < 0.05; **, P < 0.01 (repeated-measures ANOVA compared with wild type).