Table 1. Database collection from in silico searches and complementary information on selected sequences.
Pathogen | Disease | Acces. nb† | MCGH§ | MIII* § | TcPRAC Homology (%) | Annot.‡ |
Trypanosoma cruzi CL Brener | Chagas' disease | Q868H8 | C | C | 100 | PRAC |
Bacillus anthracis Ames | Anthrax | Q81PH1 | C | C | 40 | Put. PRAC |
Q81UH1 | C | C | 40 | |||
Brucella abortus 9-941 | Brucellosis | Q57B94 (1) | C | C | 40 | Put. PRAC |
Q57F22 (2) | S | T | 29 | |||
Brucella melitensis 16M | Brucellosis | Q8YJ29 | C | C | 40 | PRAC |
Q8YFD6 | S | T | 29 | |||
Brucella suis 1330 | Brucellosis | Q8FYS0 | C | C | 40 | Put. PRAC |
Q8G2I3 | S | T | 29 | |||
Burkholderia cenocepacia HI2424 | Pneumonia, sepsis | A0AZQ0 | C | C | 29 | PRAC |
A0B0B8 | C | T | 37 | |||
Burkholderia pseudomallei K96243 | Melioidosis | Q63NG7 | C | C | 34 | Hyp. prot |
Clostridium difficile 630 | Nosocomial diarrhoea | Q17ZY4 | C | C | 56 | Put. PRAC |
Pseudomonas aeruginosa PAO1 | Pneumonia, sepsis | Q9I476 | C | C | 33 | Hyp. prot |
Q9I489 | S | C | 30 | |||
Vibrio parahaemolyticus O3 :K6 | Diarrhoea | Q87Q20 | C | C | 37 | PRAC |
Sequences were obtained by blasting TcPRAC (Q868H8) against Swiss-Prot/TrEMBL or NCBI databases.
Swiss-Prot accession number;
MCGH and MIII
motifs are minimal peptide sequences encompassing TcPRAC catalytic Cys (Cys130 and Cys300) residues;
Related annotation from blast searches.