Table 2.

Difference in length of stay and hospital mortality among the three study periods

Outcome	Pre-protocol N = 2,677	Transition N = 3,513	Protocol 2,196
Observed mortality, %, (95% CI)	19.3 (17.8 – 20.8)	18.0 (16.7 – 19.3)	16.9 (15.4 – 18.5)
ICU length of stay, days, median (IQR)	1.6 (0.85–3.29)	1.4 (0.84–2.98) *	1.7 (0.91–3.14)
28-day ICU free days, days, mean ± SD	20.4 ± 10.6	20.8 ± 10.3	21.1 ± 10.0*

CI = confidence interval; ICU = intensive care unit; IQR = interquartile range; SD = standard deviation

* P < 0.05 compared to pre-protocol period