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. 2007 Jun 11;104(25):10370–10375. doi: 10.1073/pnas.0700773104

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© 2007 by The National Academy of Sciences of the USA

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Fig. 6. — LM11 inhibits ARNO-dependent migration of MDCK cells. (A) Cell sheet migration after scratch wounding analyzed by time-lapse videomicroscopy (SI Movie 1). Data were evaluated by using Student's t test. ∗, P < 0.0001. (B) Dose dependence of LM11 inhibition in noninduced and induced wild-type ARNO-expressing MDCK cells. (C) MDCK cell sheet migration was followed by time-lapse videomicroscopy in the presence of a nonsilencing siRNA (Top), of an ARNO siRNA (Middle), or of 100 μM LM11 and an ARNO siRNA (Bottom). Each colored line represents the hourly progression of the cell monolayer during the first 6 h after wounding.