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. 2007 Jun 11;104(25):10376–10381. doi: 10.1073/pnas.0700962104

Fig. 2.

Fig. 2.

Selected genes from S. tropica modular biosynthetic enzyme systems and their associated natural products. (A–D) Putative siderophore clusters. (A) sid1 cluster in comparison to the desferrioxamine cluster from Streptomyces coelicolor A3 (2). (B) sid2 cluster in comparison to the yersiniabactin cluster from Y. pestis. (C) sid3 cluster with putative product intermediate. (D) sid4 cluster in comparison to proposed S. coelicolor‘coelibactin' cluster (unconfirmed structure). (E–G) Novel modular enzyme systems. (E) salAB from proposed salinosporamide cluster. (F) lymAB from proposed lymphostin cluster. (G) slmNABCD modular PKS system from proposed salinilactam cluster (stereo chemistry proposed, green portion is derived from the proposed lysine-based starter unit). Domain notation: A, adenylation (amino acid substrate noted); C, condensation; Ccyc, condensation with cyclization; PCP, peptidyl carrier protein; KS, β-ketoacyl synthase; AT, acyl-CoA/ACP transacylase (activates malonyl-CoA unless otherwise noted); mAT, methylmalonyl-CoA/ACP transacylase; DH, dehydratase; ACP, acyl carrier protein; TE, thioesterase; OR, oxidoreductase; MT, SAM-dependent methyltransferase; NAT, N-acetyl transferase; unk, unknown.