Table 1.
S. tropica CNB-440 genome data in comparison to other actinomycete natural product producers
| Organism | Size, Mb | Chr. org. | %G+C content | %GDSM | Major NP clusters, n |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PKS |
Mixed PKS/NRPS | NRPS | Non-NRPS siderophore | ||||||||
| Modular type I | Enediyne | Type II | Type III | ||||||||
| S. tropica CNB-440 | 5.18 | C | 69.5 | ≈9.9 | 1 | 2 | 2 | 1 | 4 | 3 | 1 |
| S. coelicolor A3(2) | 8.72 | L | 72 | ≈8 | 2 | — | 2 | 3 | — | 3 | 1 |
| M. tuberculosis H5N1 | 4.41 | C | 67 | ND | 7 | — | 1 | 3* | — | 2 | — |
| Frankiasp. CcI3 | 5.43 | C | 70 | ND | 4 | — | 2 | — | 1 | 3 | 1 |
| N. farcinica IFM 10152 | 6.01 | C | 70 | ND | 4 | — | 1 | 1 | 1 | 7 | — |
NP, nonribosomal peptide; Mb, megabases; Chr. org., chromosome organization; %GDSM, percentage of the genome dedicated to secondary metabolism; C, circular; L, linear; ND, not determined; —, not applicable.
*Two type III PKS enzymes are associated with the modular type I PKSs pks7, pks8, pks9, and pks17.