Fig. 2.
Spinal delivery of the CatS inhibitor LHVS is antinociceptive in neuropathic rats. Acute injection of LHVS (50 nmol per rat) is not antiallodynic in 3-day neuropathic rats (A) but is analgesic in 7-day (B) and 14-day (C) neuropathic rats. Intrathecal injection of LHVS (10 or 50 nmol per rat) reverses established neuropathic mechanical hyperalgesia in 14-day neuropathic rats (D). ∗, P < 0.05, ∗∗∗, P < 0.001 versus vehicle (Veh) group, six to eight rats per group. PWT, paw withdrawal threshold.