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. 2007 Jun 4;104(25):10709–10713. doi: 10.1073/pnas.0704024104

Fig. 1.

Fig. 1.

Raising plasma FFA induces increased expression of genes encoding FAO enzymes in skeletal muscle. (a) Representative Western blots and average protein values of three enzymes used as markers for the mitochondrial β-oxidation pathway in epitrochlearis muscles of rats fed either a chow diet (control) or a high-fat diet (n = 7 per group). The rats on the high-fat diet were given daily heparin injections to raise FFA levels (↑FFA). MCAD, medium-chain acyl-CoA dehydrogenase; LCAD, long-chain acyl-CoA dehydrogenase; VLCAD, very long-chain acyl-CoA dehydrogenase. (b) Real time PCR analysis of mCPT-1 mRNA levels in triceps muscles of control and ↑FFA groups (n = 6 per group). (c) Palmitate oxidation by triceps muscles homogenates of the control and ↑FFA groups of rats (n = 7 per group). ∗, P < 0.05, significantly different from control.