Fig. 3.
Reproductive system defects in male Kiss1tm1PTL-null mice. (A) Reduced testes size in mutant mice. (Scale bar: 0.25 cm.) (B) Reduced development of seminal vesicle in mutant mice. (Scale bar: 0.25 cm.) (C and D) Histology of seminiferous tubules showing intact spermatogenesis and mature sperm in wild-type mice (C) and impaired spermatogenesis in mutant mice (D). (Scale bars: 50 μm.) (E and F) Histology of epididymis showing sperm in the lumen (l) in wild-type mice (E) and absence of sperm in the lumen in mutant mice (F). (Scale bars: 50 μm.) (G and H) Histology of adrenal gland showing retention of fetal zone X (arrow) in mutant male mice (H) and absence of this zone in mature male wild-type mice (G). (Scale bars: 300 μm.)