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. 2003 Jan;10(1):16–25. doi: 10.1101/lm.53703

Figure 6.

Figure 6

Spontaneous recovery of CTA. (A) Two groups of rats were subjected to CTA training on saccharin. Group I (open circles) was tested once 3 d after training. Group II (closed circles) was also tested 3 d after training, but on three successive trials, 2 h apart (i.e., massed training). The groups were then divided into subgroups, and each of the subgroups was subjected to a single extinction test at the indicated time points; that is, each of the data points at t > 0 represents a separate group. Only Group II, which was subjected to a massed-extinction protocol, displayed spontaneous recovery (closed circles, >2 h). (B) Spontaneous recovery of CTA can be blocked by the microinfusion (black arrow) into the IC of (clen) clenbuterol (1 ng, open squares), and 8-Br-cAMP (86 ng, open circles), but not by (prop) propranolol (20 μg, closed squares). Asterisks here denote significant differences (p < 0.05) in the AI of the clenbuterol and the 8-Br-cAMP groups versus the propranolol group.