Figure 1.

100-Hz long-term potentiation (LTP) does not require ERK activation in mouse hippocampus. (A) LTP induced with a pair of 100-Hz tetani in mouse hippocampal slices in the presence of either vehicle (n = 19), 10 μM SL327 (n = 11), or 20 μM U0126 (n = 10). Inset, representative traces from vehicle- and SL327-treated mouse slices before (gray) and after (black) tetanization. Scale bars are 1 mV by 8 msec. (B) LTP induced with this same induction protocol in rat hippocampal slices in the presence of either vehicle (n = 10), 10 μM SL327 (n = 7), or 20 μM U0126 (n = 5). Inset, representative traces from vehicle- and SL327-treated mouse slices before (gray) and after (black) tetanization. Scale bars are 1 mV by 8 msec. fEPSP = field Excitatory Postsynaptic Potential