Figure 2.

A decrease in N-CoR levels correlates with the acquisition of resistance to tamoxifen by human MCF-7 breast cancer cells in a mouse model. (A) Western blots of whole-cell extracts from mouse tumors were normalized for total protein and probed with α-N-CoR and α-actin antibodies. Two independent sets of tumors and extracts were used. (B) N-CoR expression levels were quantitated by Western blot densitometry and analyzed by the Wilcoxon rank-sum test. The black circle represents the mean within each data set. The box indicates the 25th–75th percentiles; the mean (•) and median (middle line) are also shown.