Fig. 5.
Details of bisdioxopiperazine compounds and ICRF-187-binding site. (a) Schematic of different bisdioxopiperazine compounds. (b) Stereo figure of drug-binding site. One protomer has been removed for clarity. ADPNP, ICRF-187, and residues within 5 Å of the drug are shown in stick representation and colored as in Fig. 3. Subtraction of the van der Waals volume of ICRF-187 (225 Å3) from the volume of the drug-binding cavity (350 Å3) reveals two unfilled cavities above and below the plane of the drug (light gray mesh cages) with volumes of 35 and 95 Å3, respectively.