Fig. 4.

Backbone model of NT(8–13) when bound to NTS-1. Backbone dihedral angle constraints as obtained from talos (see Table 1) and standard potentials were used to sample the allowed conformational space within cns (56). A representative backbone structure together with a transparent hose-shaped object reflecting the ensemble distribution of a set of 100 structures is shown. The current analysis does not permit refinement of the side-chain conformations. Hence, all side chains are shown by using thin lines and are indicated only for reference. The figure was prepared by using molmol (57).