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. 2003 Sep 5;100(19):10794–10799. doi: 10.1073/pnas.1934713100

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Copyright © 2003, The National Academy of Sciences

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Fig. 2. — Developmental abnormalities in SIRT1-deficient mice. (A) WT and SIRT1^Δ^ex4/^Δ^ex4 E16.5 embryos. *, exencephaly in the SIRT1^Δ^ex4/^Δ^ex4 embryo. (B) Whole-mount eyes from E16.5 embryos. Arrow indicates open optic fissure in the SIRT1^Δ^ex4/^Δ^ex4 eye. (C) Retinal sections from 5-week-old mice. rs, rosette-like structure. (D) An enlargement of C. gl, ganglion cell layer; ipl, inner plexiform layer; inl, inner nuclear layer; opl, outer plexiform layer; onl, outer nuclear layer; is, inner segment; os, outer segment; pe, pigmented epithelium. (E) Retinal sections from E18.5 WT and SIRT1^Δ^neo/^Δ^neo embryos. (F) Sections through E18.5 hearts. *, the VSD. LV, left ventricle; RV, right ventricle. (G) Section through E18.5 SIRT1^Δ^ex4/^Δ^ex4 heart showing elongated atrioventricular valve (arrow).