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. 2003 Sep 5;100(19):10794–10799. doi: 10.1073/pnas.1934713100

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Fig. 4. — Increased thymocyte apoptosis in SIRT1-deficient cells. (A) Western analysis of SIRT1 and SIRT1^Δ^ex4 protein in thymocytes of the indicated genotypes. (B) Western analysis of acetylated p53 in p53 IPs from SIRT1⁺^/⁺ and SIRT1^Δ^ex4/^Δ^ex4 thymocytes, at 2.5 h after mock (–) or 500 rads IR (+), in the presence of 1 μM TSA. Western analyses on the IP inputs show total p53 levels, and the arrow indicates a crossreacting band that controls for total protein. (C) The percent nonapoptotic cells in SIRT1⁺^/⁺, SIRT1⁺^/^Δ^ex4, SIRT1^Δ^ex4/^Δ^ex4, and p53^–^/^– CD4⁺ thymocytes after IR is shown.