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Activated dnTGFβRII CD8+ T cells fail to induce diabetes in RIP-CD80 and Tet-TNF-α single-tg mice. CD8+CD44+ T cells were prepared for the PLN of donor dnTGFβRII mice as before. Tet-TNF-α and Tet-TNF-α/CD80 mice were induced to express TNF-α from birth to 25 days of age. In all cases, 5-week-old recipient RIP-CD80 (▴, n = 6), Tet-TNFα (□, n = 6), or Tet-TNF-α/CD80 (♦, n = 3) mice were injected with 3 × 104 donor cells. Diabetes progression was monitored as before.
