Fig. 1.

DCD and its homologues. (A) Genomic structure of the human IBC-1/DCD gene. Exon–intron boundaries, start-and-stop codons, and the SAGE tag that led to the identification of IBC-1/DCD are indicated. (B) Evaluation of DCD expression in 76 human adult and fetal tissues on a dot-blot expression array. High level of expression was detected only in the pons of the brain, whereas low-level expression was seen in the paracentral gyrus of cerebral cortex. (C) Human IBC-1/DCD cDNA and predicted amino acid sequence. Sequences of the peptides derived from cachectic factor and survival peptide are indicated by thick and thin underlining, respectively. An arrow marks the predicted secretory signal peptidase cleavage site. (D) Amino acid alignment of DCD, lacritin, and EST-AI12471 proteins. Amino acids identical to the consensus are shaded in gray. Comparison was made by using DNAStar and the clustal algorithm.