Table 1. Biodistribution of i.v. injected 99mTc-18B7 and 99mTc-MOPC21 antibodies at 24 h postinjection in mice intratracheally infected with CN and healthy BALB/c mice.
Mice
|
||||
---|---|---|---|---|
Organ | Infected with CN, 99mTc-18B7 injection | Infected with CN, 99mTc-MOPC21 injection | Infected with CN and pretreated with 1 mg of nonradioactive 18B7 before 99mTc-18B7 injection | Healthy controls, 99mTc-18B7 injection |
Blood | 12.77 (1.22) | 9.02 (2.13) | 8.25 (0.22) | 8.0 (0.70) |
Liver | 8.71 (1.22) | 1.27 (0.34) | 6.71 (0.52) | 4.77 (0.32) |
Kidney | 9.88 (0.21) | 3.07 (1.00) | 7.26 (0.28) | 4.47 (1.31) |
Spleen | 4.86 (0.14) | 1.50 (0.09) | 2.53 (0.54) | 2.56 (0.62) |
Stomach | 2.43 (0.08) | 1.04 (0.33) | 5.39 (1.32) | 1.57 (0.35) |
Lungs | 10.27 (1.02) | 2.66 (0.50) | 4.57 (0.33) | 4.57 (0.59) |
Results were obtained from n = 3 mice per time point and were tabulated as percent initial dose per g. Numbers in parentheses are SD.