Table 2. Phenotypes and genotypes of BMS-378806-resistant viruses.
| HIV-1 | Experiment | Selection, nM | Fold resistance* | Substitutions | Frequency | Domain |
|---|---|---|---|---|---|---|
| NL 4-3 | 1 | 96 | 20 | M475I | 8/10 | C5 |
| 2 | 100 | 218 | M475I | 5/18 | C5 | |
| R350K/M475I | 4/18 | C3/C5 | ||||
| D185N/R350K/M475I | 2/18 | V2/C3/C5 | ||||
| LAI | 1 | 96 | 31 | I595F | 6/7 | gp41 |
| 384 | 1,941 | M434I | 1/8 | C4 | ||
| I595F | 2/8 | gp41 | ||||
| M434I/I595F | 4/8 | C4/gp41 | ||||
| I595F/K655E | 1/8 | gp41/gp41 | ||||
| 2 | 33 | 157 | M434I/V | 8/16 | C4 | |
| S440R | 2/16 | C4 | ||||
| V68A/M434I | 1/16 | C1/C4 | ||||
| V68A/S440R | 1/16 | C1/C4 | ||||
| M426L/K655E | 1/16 | C4/gp41 | ||||
| M434I/K655E | 1/16 | C4/gp41 | ||||
| S440R/K655E | 2/16 | C4/gp41 |
Major substitutions are shown in bold.
*
Fold changes in susceptibility, significant at the ≤0.05 level by an unpaired t test.