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| Envelope | Substitutions | EC50, nM ± SD | Fold resistance* |
|---|---|---|---|
| LAI | Wild type | 4 ± 1 | 1 |
| V68A | <15 | <4 | |
| V68A/M434I | 309 ± 72 | 77 | |
| M426L | 462 ± 158 | 116 | |
| M434I | 17 ± 2 | 4 | |
| M434I/I595F | 1,990 ± 70 | 498 | |
| I595F | 32 ± 10 | 8 | |
| NL4-3 | Wild type | 67 ± 4 | 1 |
| M475I | 2,689 ± 304 | 40 | |
| R350K | 38 ± 4 | 0.6 | |
| R350K/M475I | 1,028 ± 296 | 15 |
Major substitutions are shown in bold.
Fold resistance, EC50 for resistant variants/EC50 wild-type strains.
