Table 5. Pharmacokinetic parameters of BMS-378806 in rats, dogs, and monkeys.

Parameter	Rat	Dog	Monkey
IV/oral dose, mg/kg	1/5	0.67/3.4	0.67/3.4
Bioavailability, %	19	77	24
Oral Cmax, μM	0.22	7.4	0.51
Oral AUC0-∞, μM × h	1.3	19	3.2
Total body clearance, ml/min per kg	32	5.2	10
Steady-state volume of distribution, liters/kg	0.56	0.47	0.39
IV terminal half-life, h	0.3	1.2	0.9
Apparent oral terminal half-life, h	2.1	1.4	6.5