Fig. 3.

Sequence alignment of the MOG sequences (mMOG, mouse; rMOG, rat; bMOG, bovine; hMOG, human; qMOG, quokka), as well as closely related structural homologues CAR, JAM, and P₀. Secondary structure elements relating to the MOG structure are shown above the alignment. Identical residues are boxed and in red, and conservatively substituted residues are in blue. The major encephalitogenic peptides (1–22, 35–55, and 92–106) are shown underneath the MOG sequences. Shaded residues represent regions of sequence differences between the MOG species. Numbering was done according to the MOG sequence.