Table 1. Effect of indomethacin on serum phosphate and urinary phosphate excretion in C57/B6 and Hyp mice.
Mice | Treatment | Serum creatinine, mg/dl | Serum phosphate, mg/dl | Urine creatinine, mg/dl | Urine phosphate, mg/dl | FEPO4, % |
---|---|---|---|---|---|---|
C57/B6 | Vehicle | 0.2 ± 0.1 | 7.2 ± 0.4 | 30 ± 5 | 25.7 ± 12.0 | 2.7 ± 1.2 |
C57/B6 | Indomethacin | 0.3 ± 0.1 | 8.0 ± 0.4 | 40 ± 3 | 15.1 ± 5.7 | 2.6 ± 0.6 |
Hyp | Vehicle | 0.2 ± 0.1 | 2.9 ± 0.2* | 47 ± 6 | 80.3 ± 32.5 | 13.0 ± 3.2* |
Hyp | Indomethacin | 0.2 ± 0.2 | 4.1 ± 0.2† | 47 ± 6 | 22.5 ± 11.4 | 2.2 ± 1.1 |
In all cases, n ≥ 6
, P < 0.05 vs. other groups
, P < 0.05 vs. C57/B6, C57/B6 indomethacin, and Hyp vehicle