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TR1–41 and TR42–55 activate platelets synergistically. Diluted whole blood was incubated (22°C, 10 min) with TR1–41 and with TR42–55 at the indicated concentrations. The platelet surface binding of the P-selectin-specific mAb S12 was determined by flow cytometry. Binding is expressed as a percent of the binding with maximal thrombin (2 units/ml). Data are mean ± SEM. n = 6.
