Table 1.
Agonist | Amplitude of light transmission, % maximum | Maximum slope, % light transmission/sec | Concentration to achieve maximum aggregation | Time delay to maximum aggregation, sec | EC50 |
---|---|---|---|---|---|
Thrombin | 93.8 ± 1.2 | 1.5 ± 0.1 | 0.28 ± 0.13 units/ml | 47.5 ± 10.3 | 0.09 ± 0.01 units/ml |
TR1-41 | 68 ± 11 | 0.82 ± 0.19 | 15.3 ± 2.8 μM | 62.5 ± 16.8 | 7.25 ± 1.08 μM |
TR42-55 | 85 ± 4.7 | 1.53 ± 0.33 | 12 ± 1.2 μM | 42.7 ± 19.3 | 13 ± 2.34 μM |
TR29-45 | 1.5 ± 0.7 | NA | NA | NA | NA |
TR1-10 | 1.0 ± 0.6 | NA | NA | NA | NA |
TR1-41s | 1.0 ± 0.6 | NA | NA | NA | NA |
TR44-55i | 1.0 ± 0.4 | NA | NA | NA | NA |
TR42-55i | 1.0 ± 0.6 | NA | NA | NA | NA |
s, Scrambled; i, inactive; NA, not applicable. Data are mean ± SEM. n = 6.