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Relative neurotropism of variants cloned from the CVS-24 strain
| Virus | Adaptation/ selection | Titer, FFU/ml
|
Neurotropism index | |
|---|---|---|---|---|
| NA | BHK | |||
| CVS-24 | Mouse brain | 1.0 × 109 | 2.5 × 107 | 1.60 |
| CVS-N2c | NA cell | 2.8 × 105 | 4.0 × 103 | 1.85 |
| CVS-B2c | BHK cell | 1.0 × 108 | 4.5 × 107 | 0.35 |
Virus titers were determined by using the immunofluorescent antibody test described. The neurotropism index is the logarithm of the titer in NA cells minus the logarithm of the titer in BHK cells.
