Table 1.
Hemodynamic and pulmonary parameters
| After 3 months Sildenafil | After 6 months Sildenafil | |||||
| Parameter | Baseline | After 60 minutes Tadalafil | 60 min after the last dose | 8 h after the last dose | 60 min after 20 mg Sildenafil | |
| Systolic BP (mmHg) | 167 | 159 | 147 | 145 | 140 | |
| Diastolic BP (mmHg) | 89 | 86 | 97 | 100 | 90 | |
| Heart rate (1/min) | 75 | 87 | 93 | 69 | 75 | |
| Cardiac index (l/minm2) | 3.02 | 3.51 | 3.33 | 3.56 | ||
| Cardiac output (l/min) | 6.8 | 7.9 | 7.5 | 8.0 | ||
| Mean PAP (mmHg) | 45 | 39 | 42 | 42 | ||
| PVR (dyn·s-1·cm-5) | 459 | 344 | 352 | 360 | ||
| Central venous pressure (mmHg) | 3 | 3 | 6 | 3 | ||
| PAWP | 6 | 6 | 9 | 6 | ||
| Hepatovenous pressure gradient (mmHg) | 10 | 7 | 10 | |||
| Arterial paO2 (mmHg) | 70.5 | 78.2 | 71.4 | 76.9 | ||
| Arterial paCO2 (mmHg) | 41.3 | 38.4 | 35.3 | 31.3 | ||
| 6 min walking test (m) | 522 | 514 | 580 | |||
| VO2peak (ml/min) | 2020 | 2240 | 2640 | |||
| Watt max | 120 | 130 | 140 | |||
| VE/VO2 | 37.0 | 33.5 | 29.3 | |||
| VE/VCO2 | 35.2 | 33.2 | 27.8 | |||
Hemodynamic and pulmonary parameters after inhibition of PDE5. BP = blood pressure, PAP = pulmonary arterial pressure, PVR = pulmonary vascular resistance, VO2peak = peak oxygen uptake, VE/VO2 ventilatory equivalent of oxygen; VE/VCO2 ventilatory equivalent of carbon dioxide. PAWP = pulmonary arterial wedged pressure