Table 1.
Organism | De novo signature enzymes | Folate salvage pathway | Folate requiring enzymes | Folate independent dTMP synthesis | |||||
FolK | FolP | Dhfra | FolCb | ThyA | GlyA | Fmt | ThyX | Tdk | |
Lactobacillus acidophilus | - | - | + | + | + | + | + | - | + |
Pediococcus pentosaceus | - | - | + | + | + | + | + | - | + |
Buchnera aphidicola (3 strains) | - | - | + | + | + | + | + | - | - |
Rickettsia rickettsii | - | - | ? | + | - | + | + | + | - |
Bartonella henselae str. Houston-1 | - | - | - | - | + | + | + | - | - |
Mycoplasma hyopneumoniae (3 strains) | - | - | - | - | - | + | - | - | + |
Mycoplasma genitalium G-37 | - | - | + | - | + | + | + | - | + |
Mycoplasma synoviae 53 | - | - | + | - | + | - | + | - | + |
Ureaplasma parvum ATCC 700970 | - | - | + | - | - | - | + | - | + |
Mesoplasma florum L1 | - | - | + | + | + | + | + | - | + |
Onion yellows phytoplasma OY-M | - | - | + | + | + | + | - | - | + |
Spiroplasma kunkelii CR2-3x | - | - | + | - | + | + | + | - | + |
Borrelia burgdorferi B31 | - | - | ? | - | - | + | + | + | - |
Treponema pallidum subsp. pallidum | - | - | ? | + | - | + | + | + | - |
a Combination of the presence DHFR0, DHFR1 or DHFR2; b Combination of the presence of FolC and FolC2; (+): gene identified; blankcell with (-): no gene identified; (?): predicted missing gene