TABLE 2.
Number of BrdU-Labeled and BrdU/NeuN-Colabeled Cells in the Ipsilateral Dentate Gyrus (Mean ± SD)
| Day 15 after TBI | Day 35 after TBI | |
|---|---|---|
| BrdU+ cells (/mm) | ||
| Sham | 42 ± 13 | 5 ± 2 |
| TBI + saline | 136 ± 22 | 32 ± 3 |
| TBI + Atorvastatin | 186 ± 34a | 74 ± 13a |
| TBI + Simvastatin | 103 ± 16a,b | |
| BrdU+/NeuN+ cells (/mm) | ||
| Sham | 6 ± 2 (14%) | 2 ± 0.4 |
| TBI + saline | 26 ± 4 (19%) | 12 ± 3 (37%) |
| TBI + Atorvastatin | 48 ± 8a (25%) | 32 ± 9a (43%) |
| TBI + Simvastatin | 58 ± 7a,b (56%) |
a
p < 0.05 vs. TBI + Saline group.
b
p < 0.05 vs. TBI + Atorvastatin group.
Percentages in parentheses indicate the proportion of BrdU/NeuN-colabeled cells to BrdU-labeled cells.
BrdU, bromodeoxyuridine; NeuN, neuronal nuclei; TBI, traumatic brain injury.