Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1990 Feb;61(2):189–191. doi: 10.1038/bjc.1990.35

Phase I clinical studies with cytotoxic drugs: pharmacokinetic and pharmacodynamic considerations.

D R Newell 1
PMCID: PMC1971416  PMID: 2178663

Full text

PDF
189

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Egorin M. J., Van Echo D. A., Tipping S. J., Olman E. A., Whitacre M. Y., Thompson B. W., Aisner J. Pharmacokinetics and dosage reduction of cis-diammine(1,1-cyclobutanedicarboxylato)platinum in patients with impaired renal function. Cancer Res. 1984 Nov;44(11):5432–5438. [PubMed] [Google Scholar]
  2. Estey E., Hoth D., Simon R., Marsoni S., Leyland-Jones B., Wittes R. Therapeutic response in phase I trials of antineoplastic agents. Cancer Treat Rep. 1986 Sep;70(9):1105–1115. [PubMed] [Google Scholar]
  3. Frank S. K., Mathiesen D. A., Szurszewski M., Kuffel M. J., Ames M. M. Preclinical pharmacology of the anthrapyrazole analog oxantrazole (NSC-349174, piroxantrone). Cancer Chemother Pharmacol. 1989;23(4):213–218. doi: 10.1007/BF00451644. [DOI] [PubMed] [Google Scholar]
  4. Freireich E. J., Gehan E. A., Rall D. P., Schmidt L. H., Skipper H. E. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep. 1966 May;50(4):219–244. [PubMed] [Google Scholar]
  5. Goldsmith M. A., Slavik M., Carter S. K. Quantitative prediction of drug toxicity in humans from toxicology in small and large animals. Cancer Res. 1975 May;35(5):1354–1364. [PubMed] [Google Scholar]
  6. Grieshaber C. K., Marsoni S. Relation of preclinical toxicology to findings in early clinical trials. Cancer Treat Rep. 1986 Jan;70(1):65–72. [PubMed] [Google Scholar]
  7. Kerpel-Fronius S., Erdélyi-Tóth V., Somfai-Relle S., Csetényi J., Kovács P., Ujj G., Kanyár B. The role of comparative pharmacokinetics in the planning of human dose escalation: the experience with diacetyldianhydrogalactitol. Cancer Chemother Pharmacol. 1988;22(2):109–113. doi: 10.1007/BF00257306. [DOI] [PubMed] [Google Scholar]
  8. Smith D. B., Ewen C., Mackintosh J., Fox B. W., Thatcher N., Scarffe J. H., Vezin R., Crowther D. A phase I and pharmacokinetic study of amphethinile. Br J Cancer. 1988 Jun;57(6):623–627. doi: 10.1038/bjc.1988.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. van Hennik M. B., van der Vijgh W. J., Klein I., Elferink F., Vermorken J. B., Winograd B., Pinedo H. M. Comparative pharmacokinetics of cisplatin and three analogues in mice and humans. Cancer Res. 1987 Dec 1;47(23):6297–6301. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES