Abstract
Mothers of a population-based series of young adults with bone and soft tissue sarcoma were traced and their cancer risks estimated. No overall excess of cancers compared with expected numbers calculated from population rates was seen but mothers of patients with synovial sarcoma had significantly more cancers than expected and this was accounted for mainly by an excess of breast cancer. In addition there were strong indications that a proportion of cases were members of families with inherited cancer-prone syndromes, in particular with neurofibromatosis or with the Li Fraumeni cancer family syndrome.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Birch J. M., Hartley A. L., Blair V., Kelsey A. M., Harris M., Teare M. D., Jones P. H. Cancer in the families of children with soft tissue sarcoma. Cancer. 1990 Nov 15;66(10):2239–2248. doi: 10.1002/1097-0142(19901115)66:10<2239::aid-cncr2820661034>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
- Hartley A. L., Birch J. M., Marsden H. B., Harris M., Blair V. Neurofibromatosis in children with soft tissue sarcoma. Pediatr Hematol Oncol. 1988;5(1):7–16. doi: 10.3109/08880018809031246. [DOI] [PubMed] [Google Scholar]
- Hartley A. L., Birch J. M., Marsden H. B., Harris M. Breast cancer risk in mothers of children with osteosarcoma and chondrosarcoma. Br J Cancer. 1986 Nov;54(5):819–823. doi: 10.1038/bjc.1986.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Li F. P., Fraumeni J. F., Jr, Mulvihill J. J., Blattner W. A., Dreyfus M. G., Tucker M. A., Miller R. W. A cancer family syndrome in twenty-four kindreds. Cancer Res. 1988 Sep 15;48(18):5358–5362. [PubMed] [Google Scholar]
- Presant C. A., Russell W. O., Alexander R. W., Fu Y. S. Soft-tissue and bone sarcoma histopathology peer review: the frequency of disagreement in diagnosis and the need for second pathology opinions. The Southeastern Cancer Study Group experience. J Clin Oncol. 1986 Nov;4(11):1658–1661. doi: 10.1200/JCO.1986.4.11.1658. [DOI] [PubMed] [Google Scholar]