Figure 1 (A) Sequencing results of WT1 and CTNNB1 in normal kidney (NK), intralobar nephrogenic rest (NR), and Wilms tumour (WT) in case 1. A heterozygous WT1 mutation in exon 1 (C to A transition) and in exon 9 mutation (insertion A) in NR and WT. The CTNNB1 mutation in exon 3 (C to T transition, heterozygous) is confined to WT. (B) Sequencing results of WT1 and CTNNB1, and 11p13 loss of heterozygosity (LOH) analysis in NK, intralobar NR, and WT in case 2. The mutation in WT1 is heterozygous (deletion C) in NK but is homozygous in WT. NR and WT have LOH at 11p13 (the middle). The CTNNB1 mutation (exon 8, T to A transition) is limited to WT.