Table 3 p53 mutation profile of head and neck squamous cell carcinoma samples.
| Tumour | Stage | HPV status | Mutation | Region of protein mutated | Mutation type | R/P normal | R/P tumour |
|---|---|---|---|---|---|---|---|
| D116 | III | No | E8, nt 14456 (codon 263) (−1,FS) | Non‐conserved (before S10) | Structural | R | R |
| 222 | II | No | E5, nt 13203 (codon 175) g>a, Arg>His | Conserved (L2 Zn region) | Contact | P | P |
| 292 | III | 16 | E8 31 bp (nt 14442–14472) deletion | Conserved (S10 +splice site) | Structural | P | P |
| 308 | II | 16 | E5, nt 13203 (codon 175) g>a, Arg>His | Conserved (L2 Zn region) | Contact | R | R |
| 1332 | III | No | E4, nt 12271 (codon 116) c>g, Ser>Cys | Non‐conserved (before L1) | Contact | R | R |
| 2326 | IV | No | E6, nt 13428 (codon 223) c>t, Pro>Leu | Non‐conserved (within S7–S8) | Structural | R | R |
| 2592 | III | No | E7, nt 14074 (codon 249) g>t, Arg>Ser | Conserved (L3 DNA binding) | Contact | R/P | R |
| 4248 | III | 16 | E8, nt 14487 (codon 273) g>a, Arg>His | Conserved (S10 DNA contact) | Contact | P | P |
| 5919 | III | No | E5, nt 13107 (codon 143) t>c, Val>Ala | Non‐conserved (S3 β sandwich) | Structural | R | R |
| 5943 | II | No | E5, nt 13216 (codon 179) t>g, His>Gln | Conserved (L2) | Contact | R/P | R/P |
| 5959 | II | 16 | E8, nt 14487 (codon 273) g>a, Arg>His | Conserved (S10 DNA contact) | Contact | R/P | R/P |
| 5966 | III | No | E8, nt 14505 (codon 279) g>a, Gly>Glu | Conserved (H2) | Contact | P | P |
| 7059 | IV | No | E5, nt 13196 (codon 173) g>t, Arg>His | Conserved (L2) | Contact | R/P | R/P |
| 7999 | IV | 18 | E7, nt 14069 (codon 248) c>t, Arg>Trp | Conserved (DNA contact) | Contact | R | R |
E, exon; FS, frame shift; R, arginine allele; P, proline allele; nt, nucleotide number in the corresponding p53 sequence [NCBI accession number X54156].